Studies of Long Acting Sex Hormones

TOXICOLOGICAL STUDIES ON CERTAIN AMINOALKYL ETHERS AS POTENTIAL LONG-ACTING LOCAL ANAESTHETICS

The acute intravenous toxicities of a selection of three potential long-acting local anaesthetics belonging to the series of2- phenoxyethyldialkylamine were determined in mice. Two of the compounds were tertiary amines and the third a quaternary ammonium derivative.The I.V. median lethal dose, (LDso) of one of the tertiary compounds, 21A [N, N- diethyl-2- (2,6- diisopropyl) ethyl amine hyd...

Studies on the Relationship of the Sex Hormones to Infection

THE ESSENTIAL FINDINGS OF THESE EXPERIMENTS MAY BE SUMMARIZED AS FOLLOWS: The estrogenic hormone after being given for 1 week slows up the spread of India ink but allows it to reach and exceed a normal spread after 24 hours. After injections of the estrogenic hormone for 3 weeks the spread of India ink is much less than in the control animals. The resistance of the rabbit to vaccinia is increas...

LONG-ACTING CONTRACEPTIVE AGENTS: TESTOSTERONE ESTERS OF CYCLOALKYLCARBOXYLIC ACIDS

The synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. All esters are derivatives of cycloalkycarboxylic acids. Some of the esters possess α- , β -and/or & - substitution in the ester side-chain. The work was undertaken in order to evaluate long-acting male antifertility effect of such esters. Most of the compounds, especially compound No.1, wer...

Sex Hormones of Females

Mouse Complement: the Effect of Sex Hormones and Castration on Two of the Late-acting Components

The titer of late-acting complement components in sera from male mice is 8-10 times higher than the titer of sera from female mice. Using assays developed to measure the serum content of two of the late-acting components, we have shown that this difference is due to the effect of androgen and estrogen on these two late-acting complement components. These two components have been tentatively ide...